This document aims to encourage the participation of religious actors to support immunization programs in Latin America and the Caribbean as part of the Faith and Positive Change for Children, Families and Communities initiative. It is divided into 6 chapters detailing: 1) Background and introduction to the immunization guide, 2) Understanding immunization, 3) Faith and immunization, 4) Facilitating immunization dialogues using community engagement methodologies, 5) Promoting immunization in the faith community, 6) Monitoring and evaluating change.