Given the challenges faced with ongoing efforts to contain the spread of Ebola that arise as a result of incompatibilities between some religious and cultural practices and prescribed scientific methods, it is high time we explore ways in which traditional and religious structures can be effectively implored in combatting the spread of Ebola. Dealing with cultural and religious issues negatively affecting Ebola transmission prevention programs requires flexibility and adaptability from governments, health officials, and the people in affected communities. As Alexander et al. argue, a consideration of traditional and religious practices is critical to our understanding of transmission dynamics and subsequent control of highly infectious diseases. In this paper, we identified notable religious and traditional practices in West Africa that potentially contribute to the spread of Ebola and exacerbate the current outbreak. Our proposed strategies call for deliberate targeting of leaders of traditional and religious institutions in community-directed programs for preventive measures. As custodians of the day-to-day cultural values, traditional and religious leaders command more respect and authority in their communities than unfamiliar trained health personnel, who can be easily be viewed as having suspicious agendas.